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	<title>Joe Doliner &#187; response</title>
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		<title>What You Learned About How Asparagus Works Was Probably Wrong</title>
		<link>http://joedoliner.com/2009/07/27/what-you-learned-about-how-asparagus-works-was-probably-wrong/</link>
		<comments>http://joedoliner.com/2009/07/27/what-you-learned-about-how-asparagus-works-was-probably-wrong/#comments</comments>
		<pubDate>Mon, 27 Jul 2009 08:22:00 +0000</pubDate>
		<dc:creator>Joe Doliner</dc:creator>
				<category><![CDATA[Anecdotes]]></category>
		<category><![CDATA[science]]></category>
		<category><![CDATA[asparagus]]></category>
		<category><![CDATA[response]]></category>

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		<description><![CDATA[It&#8217;s a small quirk of human metabolism that Asparagus makes our urine smell. Due to some research in the 80s we&#8217;re now pretty darn sure that the smell is caused by a triage of sulfur containing alkyl compounds citation. But a few decades before scientists pulled out the big guns and nailed down exactly what [...]]]></description>
			<content:encoded><![CDATA[<p>It&#8217;s a small quirk of human metabolism that Asparagus makes our urine smell. Due to some research in the 80s we&#8217;re now pretty darn sure that the smell is caused by a triage of sulfur containing alkyl compounds<a href="http://www.ncbi.nlm.nih.gov/pubmed/3433805"> citation</a>. But a few decades before scientists pulled out the big guns and nailed down exactly what was causing this phenomenon, they looked at the much simpler question: &#8220;Who makes smelly urine?&#8221; Observations of the day held that many people met tales of Asparagus Urine with vacant stares, and a few studies revealed that the percentage of people making smelly urine was in the low 40s <a href="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1379934&amp;blobtype=pdf"> citation </a>. (This study was done in The UK and would probably yield very different results in other countries.)</p>
<p>So the scientists concluded, this is a polymorphism, different phenotypes existing in the same population. Some people&#8217;s digestive tracks produce the malodorous compounds, and some don&#8217;t. Simple enough right? I&#8217;ve been told they even managed to find the corresponding genotypes, and the correlation they had was great. I heard it got as far as children&#8217;s textbooks, before someone pointed out a tiny flaw in the experiment.</p>
<p>The experimenters had been a bit shy in their work. They&#8217;d fed people asparagus and asked: &#8220;Now does your pee smell?&#8221; when they should have asked the more risque: &#8220;Does his pee smell?&#8221; Had they asked the latter they would have found that ≈40% of people said yes all the time, and  ≈60% said no all the time. Because it turns out that everyone digests asparagus the same way and outputs the same urine, it&#8217;s just that not everyone can smell it.</p>
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<blockquote><p>&#8230;transforms my chamber-pot into a flask of perfume -Marcel Proust</p></blockquote>
<hr />
<p>This post was inspired by an old Daniel Miessler post which surfaced yesterday on Hacker News entitled &#8220;<a href="http://danielmiessler.com/blog/why-planes-fly-what-they-taught-you-in-school-was-wrong"> Why Planes Fly: What They Taught You In School Was Wrong </a>.&#8221; </p>
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